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The “Ask A Toxicologist” program is part of a growing effort by the College to improve public awareness and education regarding the toxicity of medication interactions, occupational chemicals, new drugs of abuse, venoms and plant toxins. The goal of the program is to provide rational, evidence-based answers to common medical toxicology questions – clearly and concisely. Members of the public are encouraged to submit questions through  for review by a panel of experts in human poisoning, who will post a consensus opinion written by one expert in the field. There is no charge for this service.
These answers are provided by volunteer medical toxicologists for the purpose of public education, and do not necessarily represent the policies or positions of the American College of Medical Toxicology.
Questions relating to an individual’s health concerns cannot be answered, as the program cannot create or replace a doctor-patient relationship. Additionally, we are unable to provide counsel, advice or interpretation for any legal issue. Questions and answers should be of a general nature, and of interest to a wide population. Not all questions will be able to be addressed.

Ask A Toxicologist

Can my dental amalgam fillings lead to mercury poisoning?

posted on 8:27 AM, April 8, 2016

Amalgam, an alloy of mercury, has been used for over 150 years in dentistry due to its low cost, durability and strength. Amalgam consists of a mixture of mercury, zinc, tin, copper and silver. There has been public concern that the mercury could pose a risk of toxicity in humans with amalgam dental work.

Multiple studies have been done to assess the possible toxicity of dental amalgam and its relation, if any, to mercury toxicity. A study in New Zealand from 1977-1997 of 20,000 patients did not find any association between dental amalgams and chronic fatigue syndrome or chronic kidney disease. Another study in which patients believed their amalgams were making them chronically ill showed that there was no association between measured mercury levels in these patients and their symptoms.

Rarely, some patients can have allergic reactions to mercury. Dental amalgams have been shown to be associated with allergic reactions to mercury. These reactions can consist of white spots in the mouth, skin rashes on the head and neck area, and mild lip swelling. These symptoms typically resolve on their own within a few days of the amalgams being placed, but in rare instances have required removal of the dental implants for resolution of symptoms. Allergy to mercury is quite rare, and reactions typically are limited to skin rashes.

A comprehensive review article published in 2012 evaluating all available studies on the risk of dental amalgams in humans concluded that the current use of dental amalgams did not pose a health risk to humans, except for those who suffered allergic reactions. Additionally, there is not sufficient evidence to justify removal of existing amalgam dental work in patients. Lastly, the authors concluded that there is no evidence that mercury released from amalgams results in adverse health effects in the general population.

In conclusion, multiple large studies have not shown any evidence that mercury released from amalgams results in adverse health effects or human toxicity. Although rarely some people may have allergic reactions to the mercury-containing dental amalgams, there is no evidence to support the removal of these amalgams, or to ban their use in dentistry. Additionally, due to the results of these many studies, the American College of Medical Toxicology included the recommendation not to remove dental amalgams in the Choosing Wisely Campaign. Individuals with dental amalgams are not at higher risk of mercury toxicity, and there is no evidence of a link between dental amalgams and mercury toxicity.


  1. Bates MN, Fawcett J, Garrett N, Cutress T, Kjellstrom T. Health effects of dental amalgam exposure: a retrospective cohort study. Int J Epidemiol. 2004;33:894–902.
  2. Pant, Vandanaa, Monika Rathore, and Archana Singh. "The Dental Amalgam Toxicity Fear: A Myth or Actuality." Toxicology International Toxicol Int 19.2 (2012): 81.
  3. Bailer J, Rist F, Rudolf A, Staehle HJ, Eickholz P, Triebig G, et al. Adverse health effects related to mercury exposure from dental amalgam fillings: toxicological or psychological causes? Psychol Med. 2001;31:255–63.
4. Forte G, Petrucci F, Bocca B. Metal allergens of growing significance: epidemiology, immunotoxicology, strategies for testing and prevention. Inflamm Allergy Drug Targets. 2008;7:145–62. Review.
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