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Toxicology Investigators Consortium (ToxIC)

 

Background

In 2009, ACMT established the ACMT Toxicology Investigators Consortium, known ToxIC. This new network of medical toxicologists was constituted to promote multi-center research in Medical Toxicology and to enable the nationwide collection of important toxicological data from patients at the bedside. ACMT thought it was incumbent to establish this network to systematically investigate these issues. As the specialty of medical toxicology has grown considerably in recent years, we now have medical toxicologists at most major medical centers, facilitating the undertaking of a nationwide toxicovigilance  program.

At ToxIC's inception an electronic survey was sent to all ACMT members asking questions on bedside medical toxicology practice patterns. Of the 114 ACMT members who answered the survey, 95 (83% of respondents) reported that they had an inpatient medical toxicology practice. In some cases, 2 or more members from the same program (or site) responded to the survey.  Taking into account duplicative responses from the same program, ToxIC identified at least 45 distinct sites that see inpatients at the bedside and record the number of patients that they see each year.  ToxIC estimated that the aggregate numbers of patients seen in the past year by these centers exceeded 14,000.  Individual site census varied from 10 to more than 1000 per year.  Most respondents expressed an interest in participating in a national research network and/or bedside based toxicovigilance system. Given this interest, work was commenced to develop a national registry. 
 
 

Creation of the ToxIC Registry

During the Fall of 2009 a test version of the ToxIC Registry was developed.  The ToxIC Registry data collection form can be found here.  Starting on January 15, 2010 four medical toxicology sites (Bellevue Medical Center, New York, NY; Porter & Littleton Adventist Hospital, Denver, CO; University of Massachusetts, Worcester, MA; and University of Texas Southwestern, Dallas TX) began to jointly pilot the initial collection of Registry data.  Collecting more than 150 cases in a 6 week period, on March 1, 2010 this collaboration was expanded to 7 additional sites to form the beta test phase of the Registry project. These additional sites were at Children's Hospital, Boston MA; Harrisburg Hospital, Harrisburg PA; Hartford Hospital, Hartford CN; Robert Wood Johnson Medical Center, New Brunswick NJ; St Mary's Hospital, Duluth MN; University of Illinois Hospital, Chicago IL; and University of Utah Hospital, Salt Lake City UT. On April 15th the final version of the Registry will go live and participation in the registry will be available to all practices in the ToxIC network, if they so chose.