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ToxIC Database Upper Level Research Projects


 Abbreviations Used Below:

ACMT ASM: American College of Medical Toxicology Annual Scientific Meeting

Acad Emerg Med: Academy of Emergency Medicine Annual Meeting

Clin Toxicol: Clinical Toxicology [Journal, Taylor Francis]

EAPCCT: European Association of Poisons Centres and Clinical Toxicologists Annual Meeting

J Med Toxicol: Journal of Medical Toxicology [Springer]

NACCT: North American Congress of Clinical Toxicology Annual Meeting

Pediatr Emerg Care: Pediatric Emergency Care [Journal, Wolters Kluwer]


 ADEs Reported in ToxIC Alcohol Intoxication

Description:  Describe the characteristics of all patients with ADEs identified in the ToxIC registry from Jan 2012 – Oct 2013.

PI:                 Brenna Farmer

Status:           Approved 2013 - Inactive

Deliverables:  Abstract 2014 ACMT ASM

Alcohol Intoxication, Co-ingestion and Withdrawal in Medical Toxicology Consultations

Description:   The Toxic Investigators Consortium (ToxIC) was developed by the American College of Medical Toxicology in January, 2010 to track patients seen by MTCS and to provide an infrastructure for research. In order to obtain information for further study, and for use in QA/QI projects involving ToxIC data entry, we reviewed and analyzed registry data regarding alcohol intoxication, co-ingestion and alcohol-withdrawal syndrome (AWS).

PI:                  Tim Wiegand

Status:           Approved 2011 (Administrative) - Inactive

Deliverables:  Abstract 2011 NACCT

Anticholinergic Treatment

Description:   Retrospective review of treatments and outcome for anticholinergic delirium 1/2012 – 12/2012

PI:                  Evan Schwarz

Status:           Approved 2013 - Inactive

Deliverables: J Med Toxicol 2015 June 11(2):179-84   

Antidotal Therapy Practices in the ToxIC Case Registry

Description:   To evaluate the current antidotal therapy practices of medical toxicologists

PI:                   Mathew Davey

Status:            Approved 2014 - Active

Deliverables:  None


 Bupropion: An Atypical Cause of Serotonin Syndrome report from the ToxIC Registry

Description:   Describe the patients with serotonin syndrome in association with bupropion as reported to the Toxicology Investigators Consortium (ToxIC).

PI:                   Diane Calello

Status:            Approved 2014 - Active

Deliverables:  Abstract 2015 ACMT ASM


 Cardiopulmonary Bypass, or ECMO, in ACMT TOXIC Registry

Description:   Describe patients who received cardiopulmonary bypass, or ECMO, found in the ToxIC database

PI:                  Sam Wang

Status:           Approved 2015 - Inactive

Deliverables:  J Med Toxicol 2015 May 27 [epub]

Cases of QT Interval Prolongation in the ToxIC Database

Description:   Our objective is to describe the cohort of cases of QT interval prolongation reported to the ToxIC (Toxicology Investigators Consortium) Registry in order to better characterize the clinical effects in these patients.

PI:                 Chris Hoyte

Status:           Approved 2013 (Administrative) - Inactive

Deliverables:  Abstract 2013 NACCT

Characteristics and Treatments of Patients with QRS Widening on behalf of the ToxIC Registry

Description:   This study will extract and characterize ToxIC cases January 1, 2014 - September 1, 2014 with QRS prolongation > 120 msec.

PI:                   Rebecca Bruccoleri

Status:            Approved 2014 - Active

Deliverables:  Abstract 2015 ACMT ASM

Characteristics of Salicylate Ingestions Reported to the ToxIC Registry

Description:   Characterize all salicylate cases within the ToxIC registry through 4-2014

PI:                  Rita McKeever

Status:           Approved 2014 - Active

Deliverables:  Abstract 2014 NACCT

Characterization of Acute Opioid Overdose in the ToxIC Registry

Description:   To gain a more comprehensive understanding of opioid overdose among the United States population, we propose using the ToxIC database to evaluate usage by age, gender, and formulation. In addition, we intend to describe intent of overdose, specifically whether the overdose was secondary to abuse, medication error, or suicide attempt.

PI:                   Katie Boyle

Status:            Approved 2014 - Active

Deliverables:  Abstract 2015 ACMT ASM

Characterization of Single Substance Baclofen Exposure in the Toxicology Investigators Consortium Registry

Description:   Analysis of ToxIC data from 1/1/2010 – 4/3/2015 limited to single substance oral baclofen exposure with descriptive statistics for patient demographics, clinical effects, therapy, level of medical care.

PI:                  James Cao

Status:           Approved 2015 - Active

Deliverables:  Abstract 2015 NACCT

Characterization of Toxic Metal Referrals

Description:   The goal of this study is to characterize patients who present to a medical toxicologist for evaluation of heavy metal exposure.

PI:                  Lynn Farrugia

Status:           Approved 2013 - Inactive

Deliverables:  Abstract 2014 ACMT ASM

Characterizing Herbals and Dietary Supplements Toxicities using the ToxIC Registry

Description:   To characterize herbals and dietary supplements toxicities using preliminary data from the ToxIC registry.

PI:                  Amy Zosel

Status:           Approved 2012 (Administrative) - Inactive

Deliverables:  Abstract 2012 NACCT 

Chelation Therapy by Medical Toxicologists in the U.S.

Description:   We investigated the Toxicologic investigators Consortium (ToxIC) Registry data of the American College of Medical Toxicologist (ACMT) to see the frequency and pattern of chelation therapy among medical toxicologists in the US.

PI:                  A. Obefami

Status:           Approved 2012 (Administrative) - Inactive

Deliverables:  Abstract 2012 NACCT

Chemically-induced Seizures in Children

Description:   Review data on the ToxIC database to look for those chemical substances that are associated with seizures in the pediatric age group.

PI:                 Yaron Finkelstein

Status:           Approved 2013 (Administrative) - Inactive

Deliverables:  Clin Toxicol 2013;51:761-6 

Clinical Characteristics of Poisoning in Women Reported in ToxIC

Description:   Review the ToxIC database through 10-2013 to identify characteristics associated with intentional and unintentional  poisoning in women.

PI:                 Jeanmarie Perrone

Status:           Approved 2013 - Inactive

Deliverables:  None

Comparison of the Severity of APAP Toxicity between the ToxIC Registry and Texas Poison Center Database

Description:   Comparative study of the severity of acetaminophen exposures reported in the ToxIC registry data and Texas Poison Center

PI:                  Jhonny Ordonez

Status:           Approved 2013 - Inactive

Deliverables:  Abstract 2014 ACMT ASM

Comparison of ToxIC and NPDS Data

Description:   Data from the ToxIC Registry (Jan 1, 2010 – Apr 1, 2011) was compared with the most recently published NPDS data from the 2009 AAPCC NPDS report.

PI:                   Kurt Kleinschmidt

Status:            Approved 2011 (Administrative) - Inactive

Deliverables:  Abstract 2011 NACCT

Comparison of VPA Exposures Treated with/without Carnitine

Description:   Comparative study of valproic acid exposures treated with carnitine vs non carnitine using ToxIC database cases through October 2013

PI:                   Jhonny Ordonez

Status:            Approved 2013 - Inactive

Deliverables:  None

Current and Emerging Trends of the Use of Observation Units by Medical Toxicologists for Poisoned Patients

Description:   Analyze ToxIC cases from 4-2010 – 12-2013 to explore the class of agents and/or the toxicologic reason for a patient being treated in an observation unit.

PI:                  Bryan Judge

Status:           Approved 2014 - Inactive

Deliverables:  J Med Toxicol 2015 Aug 15 [epub]

Current Trends in Drug Misuse in Teenagers Presenting to Emergency Care

Description:   To identify the medications and substances that were most commonly used by teenagers presenting to the ED and whose evaluation involved a medical toxicology consultation 2010-2013.

PI:                  Yaron Finkelstein

Status:            Approved 2014 - Active

Deliverables:  None

Cyanide and ToxIC Registry

Description:   Not available.

PI:                   Vikhyat Beberta

Status:             Approved 2013 - Inactive

Deliverables:    None


Drug-Induced Hallucinations in Children and Teenagers Presenting to Emergency Departments

Description:   To identify the medications and substances that were most commonly used by children and teenagers who presented to the ED with/or developed hallucinations, and whose evaluation involved a medical toxicology consultation Jan 2010 – June 2014.

PI:                   Yaron Finkelstein

Status:            Approved 2014 - Active

Deliverables:  Pediatr Emerg Care. 2015 Oct 13


 Epidemiology and Clinical Characteristics of Designer Drugs

Description:   To describe the patients in the ToxIC registry for synthetic cannabinoids and psychogenic amphetamines with respect to clinical characteristics, demographics, and evolution of epidemiology since the inception of ToxIC.the inception of ToxIC.

PI:                  Diane Calello

Status:            Approved 2014 - Active

Deliverables:  None


 Features of Synthetic Cannabinoid Exposures: Report from the ToxIC Registry

Description:   Synthetic cannabinoid (SC) exposures often prompt ED visits and toxicology consultation. All cases entered into ToxIC from 2011 to October 2014 selected as “Bath Salt, Synthetic Cannabinoid, other Designer Drug, or Agent referred to by a Street Name” were then  sorted to identify SC cases.

PI:                  Diane Calello

Status:           Approved 2014 - Active

Deliverables:  Abstract 2015 ACMT ASM

Flumazenil in the ToxIC Registry

Description:   This study aims to pilotthe utility of a toxicology registry in identifying characteristics that may influence provider’s use of flumazenil in patients poisoned with a benzodiazepine.

PI:                 Jo An Laes

Status:           Approved 2013 - Inactive

Deliverables:  Abstract 2014 NACCT


 Gender Differences in Prescription Medication Abuse

Description:   The current study aims to examine gender differences encountered in healthcare facilities with regard to the most commonly abused prescription drugs as reported in the ToxIC database 2010-2013.

PI:                  Jennifer Carey

Status:            Approved 2014 - Inactive

Deliverables:  Abstract 2014 Acad Emerg Med


Hyperkalemia Does Not Predict Outcome From Digoxin Excess in Patients With Renal Dysfunction

Description:   Single center IRB-approved retrospective chart review of all hospitalized patients with an elevated digoxin serum concentration (>1.2 ng/mL) and evaluated the correlation between plasma potassium, digoxin concentration and mortality.

PI:                 Chuck McKay

Status:           Approved 2011 (Administrative) - Inactive

Deliverables:  Abstract 2011 NACCT


Intentional Pharmaceutical Overdoses: Comparison of Self-harm, Misuse/abuse and Therapeutic Misadventure ToxIC Case Registry Entries

Description:   Retrospective review of the ACMT ToxIC Case Registry analyzing data from the intentional pharmaceutical overdoses.

PI:                   Tim Wiegand

Status:            Approved 2015 (Administrative) - Active

Deliverables:  Abstract 2015 ACMT ASM

Intentional Pharmaceutical Overdoses Related to Therapeutic Misadventures: A Description of ToxIC Entries

Description:   Retrospective review of the ACMT ToxIC Case Registry analyzing data from the intentional pharmaceutical overdoses.

PI:                   B. Abar

Status:            Approved 2015 (Administrative) - Active

Deliverables:  Abstract 2015 ACMT ASM


 Medical Toxicology Referrals in the Acute Care Setting

Description:   Medical Toxicologists (MT) evaluate patients in several different acute care settings. The types of providers whom request such services have not been defined. We queried the ToxIC Registry database to better understand the source of toxicology referrals.

PI:                  Evan Schwarz

Status:            Approved 2012 (Administrative) - Inactive

Deliverables:  Abstract 2012 NACCT


 Naloxone Administration in the Pediatric Population in ToxIC

Description:   To characterize patients age

PI:                  Laura Fil

Status:            Approved 2014 (Administrative) - Inactive

Deliverables:  Abstract 2014 ACMT ASM

Non-APAP Hepatotoxicity

Description:   What is the prevalence of non-acetaminophen (APAP) containing xenobiotics associated with AST > 1,000 as seen by medical toxicologists reporting to the ToxIC Registry (May 1, 2012 - October 30, 2013)?

PI:                  Nancy Onisko

Status:            Approved 2013 - Inactive

Deliverables:  Abstract 2014 ACMT ASM

Non-Ethanol Hyperlipasemia

Description:   Review case in the Toxicology Investigators Consortium (ToxIC) database of the American College of Medical Toxicology to investigate which xenobiotics other than ethanol were associated with hyperlipasemia.

PI:                  Jhonny Ordonez

Status:            Approved 2013 (Administrative) - Inactive

Deliverables:  Abstract 2013 NACCT


 Pediatric Laundry Detergent Pod Exposures: The ToxIC Experience

Description:    To describe the cases in ToxIC (through April 2014) involving laundry detergent pods.

PI:                  Diane Calello

Status:            Approved 2014 - Active

Deliverables:  Abstract 2014 NACCT

Poisoning during Pregnancy: Observations from ToxIC

Description:   This study reviewed data on chemical substances that are associated toxicologic disease in pregnant women as reported to ToxIC.

PI:                 Yaron Finkelstein

Status:           Approved 2012 (Administrative) - Inactive

Deliverables:  J Med Toxicol 2015 Sep;11(3):301-8.


Single-Drug Ingestions Associated with Rhabdomyolysis

Description:   Describe cases in the ToxIC database of drug-induced rhabdomyolysis

PI:                  Jen Stephani

Status:           Approved 2014 - Active

Deliverables:  Abstract 2015 ACMT ASM

Street Drug Exposures in Hospitalized Patients as Reported in the ToxIC Registry - 2010 to 2014

Description:   The purpose of this study is to evaluate the frequency of street drug exposures in hospitalized patients seen by members of the Toxicology Investigators Consortium 2010-2014.

PI:                  Anna Arroyo-Plasencia

Status:            Approved 2014 - Active

Deliverables:  None

Suicidal Adolescents: Examining Self-poisonings within the Pediatric Population

Description:   The goal of this study is to identify the most common pharmaceuticals used in pediatric self-poisonings and severity of outcomes associated with these agents.

PI:                  Lynn Farrugia

Status:            Approved 2014 - Active

Deliverables:  Abstract 2015 ACMT ASM


The Differential Use of Physostigmine by Toxicologists in Anticholinergic Toxicity based on Offending Agent

Description:   To determine the rate of physostigmine use in those who exhibited an anticholinergic toxidrome.

PI:                  Joseph Watkins

Status:            Approved 2014 - Active

Deliverables:  Abstract 2014 ACMT ASM

Toxic Exposures in Young Children Resulting in Tracheal Intubation

Description:   To determine the toxic exposures most frequently resulting in tracheal intubation in children. The Toxicology Investigators Consortium (ToxIC) Registry contains case details on all clinical consults seen by medical toxicologists via an international network.

PI:                   Ben Hatten

Status:            Approved 2014 - Inactive

Deliverables:  Abstract 2015 EAPCCT

ToxIC Registry Retrospective Investigation of Pesticide Poisoning (TRIPP)

Description:  This is a retrospective study of pesticide poisonings submitted to the TOXIC Registry, an internet-based case registry for clinical toxicology consult services. 

PI:                  Rais Vohra

Status:           Approved 2012 - Inactive

Deliverables:  None 


Understanding Relationships between Opioid Prescribing, Patient Characteristics, and Overdose

Description:   To describe the patients that present with overdose involving prescription opioid medications (POM) using information from a  prescription drug-monitoring program.

PI:                   Lindsay Fox

Status:            Approved 2014 - Active

Deliverables:  None

Use of Hemodialysis

Description:   The aim of this study to describe the use of hemodialysis in medical toxicology practice through review of the ToxIC Registry and to compare it to the AAPCC experience.

PI:                  T. Schwartz

Status:            Approved 2013 (Administrative) - Inactive

Deliverables:  Abstract 2013 NACCT

Use of Insulin-Euglycemia in Toxic

Description:   In cases of presumed single drug poisoning, what are the most common indications for medical toxicologists to use insulin euglycemia therapy?

PI:                  Paul Wax

Status:            Approved 2015 (Administrative) - Active

Deliverables:  Abstract 2015 ACMT ASM

Use of Multidose AC in the ToxIC Registry

Description:   Do current MDAC treatment practices by toxicologists involved in the Toxicologic Investigators Consortium align with published guidelines? We reviewed the ToxIC Case Registry in its entirety (2010–present) for cases involving MDAC treatment. Descriptive statistics were used for analysis.

PI:                  S. Ahari

Status:            Approved 2014 (Administrative) - Inactive

Deliverables:  Abstract 2014 ACMT ASM