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ToxIC Research

Under the direction of the ACMT Research Committee, ToxIC spearheads a series of research studies, both prospective and retrospective.

ToxIC Investigators using the Registry are invited to assume the role of Principal Investigator (PI) on studies that they propose and initiate. The option of this PI role can also be used when applying for grant funding utilizing or building on the Registry data.  The goal of ACMT ToxIC is to continue to find opportunities for the Registry to serve as a source of not only descriptive pilot data, but also a framework for the collection of enhanced primary data for use in larger, funded observational studies. As ToxIC continues to move toward this goal, it is our intention that this funding will also flow to site investigators who contribute cases.

Want to do ToxIC Research?

All researchers and fellows at active ToxIC member sites are encouraged to conduct research utilizing the Registry data. External research collaborations require individuals to actively partner with either a participating ToxIC site or with the ToxIC Consortium via the ACMT program. All individuals interested in using ToxIC data for research must submit a request to the Research Review Committee. A detailed description of the ToxIC research review process is available in the Registry's Standard Operating Procedure Archive.

Review submission requirements vary between two general study types as outlined below:

(1) Basic Descriptive Studies: Core Registry Data Only ("Upper Level")

  • Name of Primary Author/Investigator, Institution and Co-Investigators
  • Statement of formal relationship with an active ToxIC member site
  • Title of project and description of protocol (minimum of one paragraph) including main inclusion and exclusion criteria
  • Name of mentor (if PI is a Fellow-in-Training)
  • If research is to be presented at professional meeting, please specify what meeting.
  • Statement of agreement that the language “On behalf of the Toxicology Investigators Consortium” will be included for studies based on upper level  data (such as on abstract title and poster/presentation title slide).
Submission materials for upper-level core registry research review requests are accepted electronically through the form found here.
(2) Other Research Studies: Enhanced Data Requirements
Includes request requiring other retrospective data or follow back (such as chart review); other data or sample collection (e.g. survey, secondary data linkage, biological samples); establishment of a research consortium; or, request for content additions to the ToxIC registry (core or subregistry).
  • Study protocol
  • Data collection form
  • NIH Investigator biographical sketch(s)
  • Plan for authorship
  • IRB approval letter (may note as pending, but required prior to any approval)
Submission of materials for registry studies requiring enhanced data collection must be sent to
Please direct any research related questions to the ToxIC Program Manager at
Follow links below for more information on previous and on-going research utilizing the ToxIC Registry. 

Approved ToxIC Research Studies 2010-2015 

Follow links below for more information on the research studies utilizing ToxIC data to date, as well as the related publications and presentations.
  1. Approved Research Protocols
    1. ToxIC Consortium Projects
    2. ToxIC Database Sub-Registry Projects
    3. ToxIC Database Upper Level Projects
  2. Current and Previously Funded Research Studies
    1. CounterAct
    2. iN3 Emerging Drug Surveillance Network
    3. Prevention of Cardiovascular Medical Consequences of Drug Overdose
    4. North American Snake Bite Registry (NASBR) 
  3. Publications/Presentations
    1. Abstracts
    2. Manuscripts
    3. Presentations