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ToxIC Database Upper Level Research Projects
Abbreviations Used Below:
ACMT ASM: American College of Medical Toxicology Annual Scientific Meeting
Acad Emerg Med: Academy of Emergency Medicine Annual Meeting
Clin Toxicol: Clinical Toxicology [Journal, Taylor Francis]
EAPCCT: European Association of Poisons Centres and Clinical Toxicologists Annual Meeting
J Med Toxicol: Journal of Medical Toxicology [Springer]
NACCT: North American Congress of Clinical Toxicology Annual Meeting
Pediatr Emerg Care: Pediatric Emergency Care [Journal, Wolters Kluwer]
ADEs Reported in ToxIC Alcohol Intoxication
Description: Describe the characteristics of all patients with ADEs identified in the ToxIC registry from Jan 2012 – Oct 2013.
PI: Brenna Farmer
Status: Approved 2013 - Inactive
Deliverables: Abstract 2014 ACMT ASM
Alcohol Intoxication, Co-ingestion and Withdrawal in Medical Toxicology Consultations
Description: The Toxic Investigators Consortium (ToxIC) was developed by the American College of Medical Toxicology in January, 2010 to track patients seen by MTCS and to provide an infrastructure for research. In order to obtain information for further study, and for use in QA/QI projects involving ToxIC data entry, we reviewed and analyzed registry data regarding alcohol intoxication, co-ingestion and alcohol-withdrawal syndrome (AWS).
PI: Tim Wiegand
Status: Approved 2011 (Administrative) - Inactive
Deliverables: Abstract 2011 NACCT
Anticholinergic Treatment
Description: Retrospective review of treatments and outcome for anticholinergic delirium 1/2012 – 12/2012
PI: Evan Schwarz
Status: Approved 2013 - Inactive
Deliverables: J Med Toxicol 2015 June 11(2):179-84
Antidotal Therapy Practices in the ToxIC Case Registry
Description: To evaluate the current antidotal therapy practices of medical toxicologists
PI: Mathew Davey
Status: Approved 2014 - Active
Deliverables: None
Bupropion: An Atypical Cause of Serotonin Syndrome report from the ToxIC Registry
Description: Describe the patients with serotonin syndrome in association with bupropion as reported to the Toxicology Investigators Consortium (ToxIC).
PI: Diane Calello
Status: Approved 2014 - Active
Deliverables: Abstract 2015 ACMT ASM
Cardiopulmonary Bypass, or ECMO, in ACMT TOXIC Registry
Description: Describe patients who received cardiopulmonary bypass, or ECMO, found in the ToxIC database
PI: Sam Wang
Status: Approved 2015 - Inactive
Deliverables: J Med Toxicol 2015 May 27 [epub]
Cases of QT Interval Prolongation in the ToxIC Database
Description: Our objective is to describe the cohort of cases of QT interval prolongation reported to the ToxIC (Toxicology Investigators Consortium) Registry in order to better characterize the clinical effects in these patients.
PI: Chris Hoyte
Status: Approved 2013 (Administrative) - Inactive
Deliverables: Abstract 2013 NACCT
Characteristics and Treatments of Patients with QRS Widening on behalf of the ToxIC Registry
Description: This study will extract and characterize ToxIC cases January 1, 2014 - September 1, 2014 with QRS prolongation > 120 msec.
PI: Rebecca Bruccoleri
Status: Approved 2014 - Active
Deliverables: Abstract 2015 ACMT ASM
Characteristics of Salicylate Ingestions Reported to the ToxIC Registry
Description: Characterize all salicylate cases within the ToxIC registry through 4-2014
PI: Rita McKeever
Status: Approved 2014 - Active
Deliverables: Abstract 2014 NACCT
Characterization of Acute Opioid Overdose in the ToxIC Registry
Description: To gain a more comprehensive understanding of opioid overdose among the United States population, we propose using the ToxIC database to evaluate usage by age, gender, and formulation. In addition, we intend to describe intent of overdose, specifically whether the overdose was secondary to abuse, medication error, or suicide attempt.
PI: Katie Boyle
Status: Approved 2014 - Active
Deliverables: Abstract 2015 ACMT ASM
Characterization of Single Substance Baclofen Exposure in the Toxicology Investigators Consortium Registry
Description: Analysis of ToxIC data from 1/1/2010 – 4/3/2015 limited to single substance oral baclofen exposure with descriptive statistics for patient demographics, clinical effects, therapy, level of medical care.
PI: James Cao
Status: Approved 2015 - Active
Deliverables: Abstract 2015 NACCT
Characterization of Toxic Metal Referrals
Description: The goal of this study is to characterize patients who present to a medical toxicologist for evaluation of heavy metal exposure.
PI: Lynn Farrugia
Status: Approved 2013 - Inactive
Deliverables: Abstract 2014 ACMT ASM
Characterizing Herbals and Dietary Supplements Toxicities using the ToxIC Registry
Description: To characterize herbals and dietary supplements toxicities using preliminary data from the ToxIC registry.
PI: Amy Zosel
Status: Approved 2012 (Administrative) - Inactive
Deliverables: Abstract 2012 NACCT
Chelation Therapy by Medical Toxicologists in the U.S.
Description: We investigated the Toxicologic investigators Consortium (ToxIC) Registry data of the American College of Medical Toxicologist (ACMT) to see the frequency and pattern of chelation therapy among medical toxicologists in the US.
PI: A. Obefami
Status: Approved 2012 (Administrative) - Inactive
Deliverables: Abstract 2012 NACCT
Chemically-induced Seizures in Children
Description: Review data on the ToxIC database to look for those chemical substances that are associated with seizures in the pediatric age group.
PI: Yaron Finkelstein
Status: Approved 2013 (Administrative) - Inactive
Deliverables: Clin Toxicol 2013;51:761-6
Clinical Characteristics of Poisoning in Women Reported in ToxIC
Description: Review the ToxIC database through 10-2013 to identify characteristics associated with intentional and unintentional poisoning in women.
PI: Jeanmarie Perrone
Status: Approved 2013 - Inactive
Deliverables: None
Comparison of the Severity of APAP Toxicity between the ToxIC Registry and Texas Poison Center Database
Description: Comparative study of the severity of acetaminophen exposures reported in the ToxIC registry data and Texas Poison Center
PI: Jhonny Ordonez
Status: Approved 2013 - Inactive
Deliverables: Abstract 2014 ACMT ASM
Comparison of ToxIC and NPDS Data
Description: Data from the ToxIC Registry (Jan 1, 2010 – Apr 1, 2011) was compared with the most recently published NPDS data from the 2009 AAPCC NPDS report.
PI: Kurt Kleinschmidt
Status: Approved 2011 (Administrative) - Inactive
Deliverables: Abstract 2011 NACCT
Comparison of VPA Exposures Treated with/without Carnitine
Description: Comparative study of valproic acid exposures treated with carnitine vs non carnitine using ToxIC database cases through October 2013
PI: Jhonny Ordonez
Status: Approved 2013 - Inactive
Deliverables: None
Current and Emerging Trends of the Use of Observation Units by Medical Toxicologists for Poisoned Patients
Description: Analyze ToxIC cases from 4-2010 – 12-2013 to explore the class of agents and/or the toxicologic reason for a patient being treated in an observation unit.
PI: Bryan Judge
Status: Approved 2014 - Inactive
Deliverables: J Med Toxicol 2015 Aug 15 [epub]
Current Trends in Drug Misuse in Teenagers Presenting to Emergency Care
Description: To identify the medications and substances that were most commonly used by teenagers presenting to the ED and whose evaluation involved a medical toxicology consultation 2010-2013.
PI: Yaron Finkelstein
Status: Approved 2014 - Active
Deliverables: None
Cyanide and ToxIC Registry
Description: Not available.
PI: Vikhyat Beberta
Status: Approved 2013 - Inactive
Deliverables: None
Drug-Induced Hallucinations in Children and Teenagers Presenting to Emergency Departments
Description: To identify the medications and substances that were most commonly used by children and teenagers who presented to the ED with/or developed hallucinations, and whose evaluation involved a medical toxicology consultation Jan 2010 – June 2014.
PI: Yaron Finkelstein
Status: Approved 2014 - Active
Deliverables: Pediatr Emerg Care. 2015 Oct 13
Epidemiology and Clinical Characteristics of Designer Drugs
Description: To describe the patients in the ToxIC registry for synthetic cannabinoids and psychogenic amphetamines with respect to clinical characteristics, demographics, and evolution of epidemiology since the inception of ToxIC.the inception of ToxIC.
PI: Diane Calello
Status: Approved 2014 - Active
Deliverables: None
Features of Synthetic Cannabinoid Exposures: Report from the ToxIC Registry
Description: Synthetic cannabinoid (SC) exposures often prompt ED visits and toxicology consultation. All cases entered into ToxIC from 2011 to October 2014 selected as “Bath Salt, Synthetic Cannabinoid, other Designer Drug, or Agent referred to by a Street Name” were then sorted to identify SC cases.
PI: Diane Calello
Status: Approved 2014 - Active
Deliverables: Abstract 2015 ACMT ASM
Flumazenil in the ToxIC Registry
Description: This study aims to pilotthe utility of a toxicology registry in identifying characteristics that may influence provider’s use of flumazenil in patients poisoned with a benzodiazepine.
PI: Jo An Laes
Status: Approved 2013 - Inactive
Deliverables: Abstract 2014 NACCT
Gender Differences in Prescription Medication Abuse
Description: The current study aims to examine gender differences encountered in healthcare facilities with regard to the most commonly abused prescription drugs as reported in the ToxIC database 2010-2013.
PI: Jennifer Carey
Status: Approved 2014 - Inactive
Deliverables: Abstract 2014 Acad Emerg Med
Hyperkalemia Does Not Predict Outcome From Digoxin Excess in Patients With Renal Dysfunction
Description: Single center IRB-approved retrospective chart review of all hospitalized patients with an elevated digoxin serum concentration (>1.2 ng/mL) and evaluated the correlation between plasma potassium, digoxin concentration and mortality.
PI: Chuck McKay
Status: Approved 2011 (Administrative) - Inactive
Deliverables: Abstract 2011 NACCT
Intentional Pharmaceutical Overdoses: Comparison of Self-harm, Misuse/abuse and Therapeutic Misadventure ToxIC Case Registry Entries
Description: Retrospective review of the ACMT ToxIC Case Registry analyzing data from the intentional pharmaceutical overdoses.
PI: Tim Wiegand
Status: Approved 2015 (Administrative) - Active
Deliverables: Abstract 2015 ACMT ASM
Intentional Pharmaceutical Overdoses Related to Therapeutic Misadventures: A Description of ToxIC Entries
Description: Retrospective review of the ACMT ToxIC Case Registry analyzing data from the intentional pharmaceutical overdoses.
PI: B. Abar
Status: Approved 2015 (Administrative) - Active
Deliverables: Abstract 2015 ACMT ASM
Medical Toxicology Referrals in the Acute Care Setting
Description: Medical Toxicologists (MT) evaluate patients in several different acute care settings. The types of providers whom request such services have not been defined. We queried the ToxIC Registry database to better understand the source of toxicology referrals.
PI: Evan Schwarz
Status: Approved 2012 (Administrative) - Inactive
Deliverables: Abstract 2012 NACCT
Naloxone Administration in the Pediatric Population in ToxIC
Description: To characterize patients age
PI: Laura Fil
Status: Approved 2014 (Administrative) - Inactive
Deliverables: Abstract 2014 ACMT ASM
Non-APAP Hepatotoxicity
Description: What is the prevalence of non-acetaminophen (APAP) containing xenobiotics associated with AST > 1,000 as seen by medical toxicologists reporting to the ToxIC Registry (May 1, 2012 - October 30, 2013)?
PI: Nancy Onisko
Status: Approved 2013 - Inactive
Deliverables: Abstract 2014 ACMT ASM
Non-Ethanol Hyperlipasemia
Description: Review case in the Toxicology Investigators Consortium (ToxIC) database of the American College of Medical Toxicology to investigate which xenobiotics other than ethanol were associated with hyperlipasemia.
PI: Jhonny Ordonez
Status: Approved 2013 (Administrative) - Inactive
Deliverables: Abstract 2013 NACCT
Pediatric Laundry Detergent Pod Exposures: The ToxIC Experience
Description: To describe the cases in ToxIC (through April 2014) involving laundry detergent pods.
PI: Diane Calello
Status: Approved 2014 - Active
Deliverables: Abstract 2014 NACCT
Poisoning during Pregnancy: Observations from ToxIC
Description: This study reviewed data on chemical substances that are associated toxicologic disease in pregnant women as reported to ToxIC.
PI: Yaron Finkelstein
Status: Approved 2012 (Administrative) - Inactive
Deliverables: J Med Toxicol 2015 Sep;11(3):301-8.
Single-Drug Ingestions Associated with Rhabdomyolysis
Description: Describe cases in the ToxIC database of drug-induced rhabdomyolysis
PI: Jen Stephani
Status: Approved 2014 - Active
Deliverables: Abstract 2015 ACMT ASM
Street Drug Exposures in Hospitalized Patients as Reported in the ToxIC Registry - 2010 to 2014
Description: The purpose of this study is to evaluate the frequency of street drug exposures in hospitalized patients seen by members of the Toxicology Investigators Consortium 2010-2014.
PI: Anna Arroyo-Plasencia
Status: Approved 2014 - Active
Deliverables: None
Suicidal Adolescents: Examining Self-poisonings within the Pediatric Population
Description: The goal of this study is to identify the most common pharmaceuticals used in pediatric self-poisonings and severity of outcomes associated with these agents.
PI: Lynn Farrugia
Status: Approved 2014 - Active
Deliverables: Abstract 2015 ACMT ASM
The Differential Use of Physostigmine by Toxicologists in Anticholinergic Toxicity based on Offending Agent
Description: To determine the rate of physostigmine use in those who exhibited an anticholinergic toxidrome.
PI: Joseph Watkins
Status: Approved 2014 - Active
Deliverables: Abstract 2014 ACMT ASM
Toxic Exposures in Young Children Resulting in Tracheal Intubation
Description: To determine the toxic exposures most frequently resulting in tracheal intubation in children. The Toxicology Investigators Consortium (ToxIC) Registry contains case details on all clinical consults seen by medical toxicologists via an international network.
PI: Ben Hatten
Status: Approved 2014 - Inactive
Deliverables: Abstract 2015 EAPCCT
ToxIC Registry Retrospective Investigation of Pesticide Poisoning (TRIPP)
Description: This is a retrospective study of pesticide poisonings submitted to the TOXIC Registry, an internet-based case registry for clinical toxicology consult services.
PI: Rais Vohra
Status: Approved 2012 - Inactive
Deliverables: None
Understanding Relationships between Opioid Prescribing, Patient Characteristics, and Overdose
Description: To describe the patients that present with overdose involving prescription opioid medications (POM) using information from a prescription drug-monitoring program.
PI: Lindsay Fox
Status: Approved 2014 - Active
Deliverables: None
Use of Hemodialysis
Description: The aim of this study to describe the use of hemodialysis in medical toxicology practice through review of the ToxIC Registry and to compare it to the AAPCC experience.
PI: T. Schwartz
Status: Approved 2013 (Administrative) - Inactive
Deliverables: Abstract 2013 NACCT
Use of Insulin-Euglycemia in Toxic
Description: In cases of presumed single drug poisoning, what are the most common indications for medical toxicologists to use insulin euglycemia therapy?
PI: Paul Wax
Status: Approved 2015 (Administrative) - Active
Deliverables: Abstract 2015 ACMT ASM
Use of Multidose AC in the ToxIC Registry
Description: Do current MDAC treatment practices by toxicologists involved in the Toxicologic Investigators Consortium align with published guidelines? We reviewed the ToxIC Case Registry in its entirety (2010–present) for cases involving MDAC treatment. Descriptive statistics were used for analysis.
PI: S. Ahari
Status: Approved 2014 (Administrative) - Inactive
Deliverables: Abstract 2014 ACMT ASM
