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ToxIC IN3 Registry: NIDA National Early Warning System Network (iN3)


A National Institute on Drug Abuse (NIDA) funded study to Wright State University (#1R56DA038366-01), the innovative NIDA National Early Warning System Network (iN3), seeks to describe the epidemiology of emerging synthetic drugs of abuse and new drug practices with an ultimate goal to decrease the burden of substance abuse by establishing a national emerging drug surveillance network. Unlike current methods for understanding emerging drug use practices that rely on information form random patient encounters, sporadic case reports, or press reports that lack clinical accuracy, the iN3 study aims to create a standardized, integrated method for analyzing multiple data streams -- at the clinical, social and community level. Under the direction of the Principal Investigators, Dr. Robert Carlson (Wright State University), Dr. Amit Sheth (Wright State University), and Dr. Edward Boyer (Harvard University), this one-year project includes two major data streams, one being the ToxIC iN3 sub registry and the second arm being the surveillance of social media using state-of-the-art computer techniques.

Under a sub award to ACMT, one iN3 mined data source on emerging drug use includes a network of 11 sentinel sites derived from ToxIC. As a major data collection component of this larger study, medical toxicologists at these sentinel sites identify potential study eligible cases that include patients abusing a new substance or using an old substance in a new way, incidents indicating an outbreak of a new drug, or an old drug with unanticipated clinical effects. Supplemental data within this iN3 registry builds on the core ToxIC practices by focusing on qualitative interviews regarding patients' knowledge, attitudes, beliefs, and practices related to drug use, as well as additional data on past medical history, drug use and drug testing information.

By better describing the epidemiology of emerging drugs of abuse and new drug use practices, this work will help improve the ability to detect, evaluate and respond to emerging patterns of drug use through public health action, policy development and derivation of additional research targets.

Authorship Guidelines for the IN3 Registry

All medical toxicologists who contribute cases to the registry may be listed as members of the ToxIC IN3 work group, which will be credited in all publications stemming from the registry to the degree permitted by the editorial policies of any journal to which submissions are made. Individuals with significant administrative involvement in the development and maintenance of the registry will also be considered part of the group. 

Contact Information

Sharan Campleman, PhD MPH DABT ACMT
Program Manager, Toxicology Investigators Consortium (ToxIC)

Download and review the new IN3 Registry form.