ARCHIVES OCT 17 > PEHSU Webinars > PEHSU Journal Club November 2015

PEHSU Journal Club Webinar

This in-depth and interactive series provides a platform for learning and discussion about issues that focus on current and emerging aspects of pediatric and reproductive environmental health.

November 18, 2015, 1PM EDT

Hormesis: Do Little Things Matter?

The presenter will begin by describing the study methodologies used in the journal articles to be discussed. This will be followed by a discussion of the results of the studies under consideration and implications for current clinical and public health practice. The presenter will conclude by discussing preventive steps that can be taken to decrease exposure to endocrine disruptors as evidenced in the journal articles.


Articles to be discussed:

1. Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities.
Ashby J, Tinwell H, Odum J, and Lefevre P 
Environmental Health Perspectives; 112(8): 847-853

2. Evidence for hormesis in mutagenicity dose-response relationships.
Calabrese EJ, Stanek EJ 3rd, and Nascarella MA
Mutation Research 2011; 726(2): 91-97

3. An illusion of hormesis in the Ames test: Statistical significance is not equivalent to biological significance.
Zeiger E and Hoffmann GR
Mutation Research 2012; 746(1): 89-93

Learning Objectives

At the conclusion of this activity, attendees should be able to:
  • Understand the theory of hormesis.
  • Explain the controversy of hormesis as described in the Ames Test research.
  • Describe how natural variability may influence research on hormesis.

Presenter: Jennifer Lowry, MD, FACMT

Jennifer Lowry, MD, FACMT
Medical Director, Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation
University of Washington
Children's Mercy Kansas City
Kansas City, MO
Jennifer Lowry, MD, FACMT, attended medical school at the University of South Dakota School of Medicine in Vermillion and Rapid City, South Dakota. Subsequently, she completed a Pediatric Residency and Clinical Pharmacology/Medical Toxicology Fellowship at the Children's Mercy Hospital and Clinics in Kansas City, MO. She is board certified in Pediatrics and Medical Toxicology. She spent 5 years at the University of Kansas Medical Center as the Medical Director to the University of Kansas Hospital Poison Control Center. Currently, she is the Chief for the Section of Clinical Toxicology at Children's Mercy Hospital and an Associate Professor in Pediatrics at the University of Missouri \u2013 Kansas City School of Medicine. She continues to serve as a toxicologist for the KUH-PCC.
She has served as the Director for the Mid-America Pediatric Environmental Health Specialty Unit for EPA Region 7 (Iowa, Kansas, Missouri and Nebraska) since its inception in 2002 and as a medical toxicology liaison to the Region 7 Agency for Toxic Substances and Disease Registry. She is a current member of the Children's Health Protection Advisory Committee for the Environmental Protection Agency and the Chair-Elect for the American Academy of Pediatrics' Council on Environmental Health.
She is a frequently invited lecturer on pediatric toxicology and environmental exposures in the region. In addition, she has been Co-Director to multiple courses on toxicology and pediatric environmental health.

Webinar Details and Registration Information

Date and Time:
Wednesday, November 18, 2015 1:00 pm, Eastern Standard Time (New York)
Wednesday, November 18, 2015 12:00 pm, Central Standard Time (Chicago)
Wednesday, November 18, 2015 11:00 am, Mountain Standard Time (Denver)
Wednesday, November 18, 2015 10:00 am, Pacific Standard Time (San Francisco)

To register for the online event
1. Click here to register 
2. Click "Register".
3. On the registration form, enter your information and then click "Submit".

You will receive a confirmation email message with instructions on how to join the event. If you have not pre-registered, you will have the option to "Join the Event Now". You will also receive an email link. 

Continuing Education information coming soon. Please check final announcement for details.



This material was supported by the American College of Medical Toxicology (ACMT) and funded (in part) by the cooperative agreement FAIN: U61TS000238 from the Agency for Toxic Substances and Disease Registry (ATSDR).

Acknowledgement: The U.S. Environmental Protection Agency (EPA) supports the PEHSU by providing partial funding to ATSDR under Inter-Agency Agreement number DW-75-95877701. Neither EPA nor ATSDR endorse the purchase of any commercial products or services mentioned in PEHSU publications