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FAQs - Theoretical and experimental issues regarding COVID-19 and ACE receptors > Are ACE2 receptors the “final common pathway” for COVID-19 viral entry into cells?

Are ACE2 receptors the “final common pathway” for COVID-19 viral entry into cells?

posted on 8:03 PM, May 12, 2020

The ACE2 enzyme allows entry of the SARS CoV-2 virus into cells, facilitating endocytosis with additional modifications at the plasma membrane by proteins like TMPRSS2 or furan.

REFERENCES:

Sparks MA, Hiremath S, et al. The coronavirus conundrum: ACE2 and hypertension edition. NephJC 2020 – last updated May 4, 2020. Accessed May 12, 2020 at: http://www.nephjc.com/news/covidace2

 

Weiss S, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 2005;69(4):635–664. Accessed May 11, 2020 at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1306801/pdf/0007-05.pdf