ACMT Highlights Antidotal Therapies in the June issue of the Journal of Medical Toxicology - May 28, 2014
posted on 6:04 AM, June 26, 2014
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The June 2014 issue of the Journal of Medical Toxicology, the official journal of the American
College of Medical Toxicology, features articles on antidotes including lipid emulsion therapy,
flumazenil, and atropine.
Phoenix, Arizona (PRWEB) May 28, 2014 -- The June issue of the Journal of Medical Toxicology (JMT)
features several cutting edge papers that examine the safety and benefit of various antidotes, some old and some
new. One of the highlights from the issue is the largest published case series of the antidotal use of intravenous
lipid emulsion (ILE) therapy for treatment of drug overdose from the LIPAEMIC Study Group, an international
multi-center collaboration. Intravenous lipid emulsion has been called “miracle fat” because of its ability to
save patients with cardiovascular collapse from toxicity related to local anesthetic agents. LIPAEMIC’s new
report from data collected using a prospective online registry describes recovery from cardiac arrest in several
patients with anesthetic as well as non-anesthetic drug overdoses. Although few adverse effects were noted, the
authors emphasize that additional clinical trials are warranted “to further define the role of ILE in clinical
toxicology.” The large number of cases adds important new knowledge to the evolving literature on ILE.
Flumazenil, an older antidote used to reverse the effects of benzodiazepines, is the subject of a novel study also
featured in the June issue. Philip Moore, MD and colleagues in Pennsylvania propose flumazenil as a means to
diagnose benzodiazepine-induced delirium after treatment of alcohol withdrawal syndrome. The clinical
benefits of flumazenil have been hotly debated for more than 20 years, and this new study will generate much
discussion among toxicologists as illustrated by Lewis Nelson, MD of the New York City Poison Control
Center in his elegant commentary entitled “Alcohol Withdrawal and Flumazenil: Not for the Faint of Heart.”
Other highlights include a comparison of atropine regimens for treatment of organophosphate poisoning, a 10-
year review of nutmeg ingestions, and an important study that evaluates different treatment strategies for
complicated bleeding associated with dabigatran use. These articles, and many other regular features, are
available in the June edition of JMT (Volume 10, Issue 2).
ACMT is a professional, nonprofit association of physicians with recognized expertise in medical toxicology.
The College is dedicated to advancing the science and practice of medical toxicology through a variety of