Grants

Active Grants

American Academy of Addiction Psychiatry – Opioid Response Network ToxIC Novel Opioid and Stimulant Exposures (NOSE) Project

Project Grant ID: 1H79TI083343 SAMHSA/AAAP-ORN
Chief Investigators: Spyres, Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2020-2022

Synopsis: The purpose of this agreement is to identify novel opioids and psychostimulants using ToxIC’s enhanced sentinel event detection instrument and generate reports for our members and public health stakeholders. 

FDA ACMT COVID-19 ToxIC (FACT) Pharmacovigilance Project

Project Contract ID: 75F40119D10031 FDA
Chief Investigators: Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2020-2021

Synopsis: The purpose of this agreement is to provide the Food and Drug Administration (FDA) a mechanism for enhanced collection of safety data related to drug therapies used in patients treated for COVID-19.

Predicting Medical Consequences of Novel Fentanyl Analog Overdose Using ToxIC

Project Grant ID: 3R01DA048009-01A1S1 NIH/NIDA/Icahn School of Medicine
Chief Investigators: Manini, Wax, Brent
Administering Institutions: Icahn School of Medicine at Mount Sinai, American College of Medical Toxicology
Funding period: 2020-2025

Synopsis: The purpose of this grant is to investigate the risk factors, characterize the novel synthetic opioids used, evaluate the optimal treatments and track regional trends in fentalog overdoses by using the ACMT ToxIC Registry network.

Center for Disease Control and Prevention (CDC) – ToxIC Registry Access

Project Contract ID: 75D30120C07819 CDC
Chief Investigators: Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2020-2023

Synopsis: The purpose of this agreement is to provide the CDC National Center for Injury Prevention and Control (NCIPC) Division of Overdose Prevention (DOP) access to the ToxIC Registry for surveillance and research projects of mutual interest. 

Food and Drug Administration (FDA) – ToxIC Registry Access

Project Contract ID: 75F40119D10031 FDA
Chief Investigators: Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2016-2024

Synopsis: The purpose of this agreement is to provide the FDA Office of Clinical Pharmacology (OCP) access to the ToxIC Registry for surveillance and research projects of mutual interest. 

North American Snakebite Registry

Project Contract ID: BTG
Chief Investigators: Ruha, Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2013-2023

Synopsis: The purpose of this grant is to develop and maintain a detailed patient registry on snakebite envenomation cases seen in the United States using the ACMT ToxIC Registry Program

Completed Grants

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Prevention of Cardiovascular Complications from Drug Overdose Emergencies

Project Grant ID: 1R01DA037317 NIH/NIDA
Chief Investigators: Manini, Wax, Brent
Administering Institutions: Mount Sinai School of Medicine
Funding period: 2014-2019

Synopsis: A prospective cohort study of ED overdose patients to 1) evaluate high risk genetic polymorphisms that are predictive of drug overdose fatality; (2) Evaluate serum biomarkers that predict tissue/organ injury from drug toxicity; and (3) prospectively validate a previously derived clinical risk tool in the Toxicology Investigators’ Consortium (TOXIC), a robust registry of over 70 hospital centers with bedside medical toxicology evaluation of ED overdose patients.

NIDA National Early Warning System Network (iN3): An Innovative Approach

Project Grant ID: R56 1 R56DA038366 NIH/NIDA
Chief Investigators: Carlson, Sheth, Boyer, Wax, Brent
Administering Institutions: Wright State University
Funding period: 2014-2016

Synopsis: The goal of this study is to establish an advanced surveillance system for emerging drug use in the U.S. by harmonizing data from web-based sources associated with emerging drug use and a network of sentinel sites for emerging drug use staffed by medical toxicologists.

Supplemental Translational Proposal for the Utilization of the ToxIC Network to Study High Dose Chemical Threat Agent Exposures in Humans

Project Grant ID: WA00190374/RFS2014140 NIH/NINDS
Chief Investigators: Bird, Wax, Brent, Hatten
Administering Institutions: University of Massachusetts
Funding period: 2013-2014

Synopsis: The purpose of this supplemental award is to investigate the use of the Toxicology Investigators Consortium (ToxIC) Registry for clinical information on actual cases of chemical threat agent poisoning.

NDEWS – Development of ToxIC Briefs

Project Grant ID: Subcontract to the NIDA funded National Drug Early Warning System (NDEWS)
Chief Investigators: Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2018-2019

Synopsis: The purpose of this agreement is to provide pilot funding to develop ToxIC Briefs – short form reports from the ToxIC Registry – that would serve as a means to disseminate observations from the ToxIC Registry to the NDEWS program who then disseminate these reports to their vast array of partners with an interest in novel drugs of abuse.