Recipients of Prior Grant Opportunities
Advancing research is an important part of the Medical Toxicology Foundation’s mission. We are honored to have supported these investigators and their forward-thinking projects:
Powell Graham, MD
University of Massachusetts Medical School
“CannFall: Evaluating Blood Biomarkers of Cannabis Use After Geriatric Falls”
Award Amount: $10,000
Funding Period: 7/1/2021 – 6/30/2022
Carolyn Fox, MD, and colleagues
Atrium Health's Carolinas Medical Center
"Platelet Mitochondrial Dysfunction in Acute Acetaminophen Toxicity and with 4-Methylpyrazole Treatment"
Award Amount: $10,823.11
Funding Period: July 1, 2020-June 30, 2021
David Liss, MD, and colleagues
Washington University School of Medicine
"Liquid Chromatography Tandem-Mass Spectrometry as a Universal Screening Modality for High-Risk Pregnant Patients"
Award Amount: $10,000
Funding Period: July 1, 2020-June 30, 2021
Additional institutional research award: The title of the award and project are:
Washington University Institute for Public Health’s 2022 Next Steps in Public Health. “Early Identification of Opioid and other Substance use in Pregnant Patients in Acute Care Environments”
Andrew Micciche, MD and colleagues
University of Pittsburgh
"Case-Control Study Comparing the Expression of GABAA and NMDA Receptor Subunits in Human Peripheral Blood Mononuclear Cells in Individuals With and Without Benzodiazepine-Resistant Alcohol Withdrawal”
Award Amount: $10,000
Funding Period: July 1, 2019-June 30, 2020
Michael Toce, MD, and colleagues
Boston Children’s Hospital
“Effect of Prescription Drug Monitoring Programs on Pediatric Opioid Prescribing and Opioid-related Overdoses”
Award Amount: $6,625
Funding Period: July 1, 2019-June 30, 2020
Abstract: Michael S Toce, Karen Olson, Michael C Monuteaux, Florence T Bourgeois. Impact of Prescription Drug Monitoring Programs on Adolescent and Young Adult Opioid Prescribing. J. Med. Toxicol. 16, 116–168 (2020 ASM)
Published: Toce MS, Michelson KA, Hudgins JD, et al. Association of Prescription Drug Monitoring Programs with Opioid Prescribing and Overdose in Adolescents and Young Adults. Ann Emerg Med. January 2023:1-9. doi:10.1016/j.annemergmed.2022.11.003
David Jang, MD, MSc
Co-Investigator: Utsha Khatri, MD
University of Pennsylvania Perelman School of Medicine
Investigation of a cell-permeable mitochondrial prodrug (NV-118) on mitochondrial function in human blood cells from patients with CO poisoning
Award Amount $10,000
Publications:
- Jang, D.H., Khatri, U.G., Mudan, A., Love J.S., Owiredu, S., Eckmann, D.M. Translational Application of Measuring Mitochondrial Functions in Blood Cells Obtained from Patients with Acute Poisoning. J. Med. Toxicol. (2018). https://doi.org/10.1007/s13181-018-0656-6
- David H. Jang, MD, MSc, Utsha G. Khatri, MD, Brenna P Shortal, BS, Matthew Kelly, MD, David Lambert, MD, Kevin Hardy, MD, David M. Eckmann, PhD, MD: Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Medicine Experimental Jan 2017.
Grant: National Heart, Lung and Blood Institute (NHLBI) Mentored Physician Scientist Research Career Development Award (K08HL136858)
Kathryn Kopec, DO
Carolinas Medical Center
Global Educational Toxicology toolkit (GETKIT): A One Day Course for Teaching Poisoning Essentials in Low and Middle Income Countries (LMIC)
Award Amount: $9,680
Abstract: Kathryn Kopec, Rais Vohra, Cynthia Santos, Ziad Kazzi, Anselm Wong. Global Educational Toxicology Toolkit (GETKIT): 1-Day Course in Poisoning Essentials in Low- and Middle-Income Countries: Development and Pilot Data. Lightning Oral Abstract, ASM 2019.
Peter Chai, MD
University of Massachusetts Medical School
Naloxone Distribution Patterns in Patients with a History of Heroin Abuse
Award Amount $10,000
Abstract: Lai J, Chai PR, Boyle K, Boyer EW. Acceptance Among Heroin Users of Advanced Technology in Studying Naloxone Distribution Programs. J Med Toxicol 2017;13:13.
Publication: Lai J, Champan B, Boyle KL, Boyer EW, Chai PR. Low-Energy Bluetooth for Detecting Real-World Penetrance of Bystander Naloxone Kits: A Pilot Study. Proceedings of the Hawaii International Conference on System Sciences-51. Proc Annu Hawaii Int Conf Syst Sci. 2018 Jan 3; 2018: 3253–3258.
Jennifer Carey, MD
University of Massachusetts Medical Center
Adolescent at Risk: Intentional toxic exposures in self-harm attempts and the role of social media.
Award Amount $6,042
Abstracts:
- Chapman BP, Nader N, Lai J and Carey JL. #HelpMe Social Media Usage Among Suicidal Adolescents. UMass Center for Health and Social Media Conference, Worcester, MA. May 2017
- Chapman BP, Lai J, Nader N and Carey JL. Do adolescents post social media content indicative of self-harm and intentional poisonings? J Med Toxicol 2017;13:3-46 Abstract #103
- #HelpMe Social Media Usage Among Suicidal Adolescents. UMMS CCTS Community Engagement and Research Symposium, Worcester, MA. March 2017
Publication: Carey JL, Chapman B, Chai P, Jake-Schoffman DE, Carreiro S, Nader N, Pagoto S. Social Media and Self Harm: The use of social media in depressed and suicidal youth. Proc Annu Hawaii Int Conf Syst Sci. (accepted)
Christine Murphy, MD
Carolinas Medical Center
A pilot study of the efficacy of hydroxocobalamin in treating nifedipine-induced shock.
Award Amount: $11,000
Abstracts:
- Murphy CM, Williams C, Quinn M, Nicholson B, Shoe T, Beuhler MC, Kerns WP. Pilot trial of lipid rescue in a swine model of severe nifedipine toxicity. J Med Toxicol. 2013;9:82
- Murphy CM, Williams C, Quinn M, Nicholson B, Shoe T, Dulaney AR, Beuhler MC, Kerns WP. Pilot study comparing hemodynamic measures in swine anesthetized with α-chloralose and isoflurane. Clin Toxicol 2014;52:358
- Murphy CM, Williams C, Quinn M, Nicholson B, Shoe T, Dulaney AR, Beuhler MC, Kerns WP. Survival of swine with nifedipine toxicity treated with methylene blue. J Med Toxicol 2014;10:69
- Murphy CM, Gellar M, Runyon MS, Rozario N, Kerns W. Efficacy of Hydroxocobalamin in Treating Nifedipine Induced Shock. J Med Toxicol 2016;12:5-6
Publication: Murphy CM, Williams C, Quinn ME, Nicholson T, Shoe T, Beuhler MC, Kerns WP. Pilot trial of intravenous lipid emulsion treatment for severe nifedipine-induced shock. J Med Toxicol. 2016;12:380-5 PMID:27501853
Katherine Katzung, MD
HealthPartners Institute for Education & Research/Regions Hospital
Effect of Norepinephrine on Cerebral Oxygenation in a Porcine Model of Propranolol Toxicity After Maximization of High Dose Insulin (HDI) Therapy.
Award Amount $13,922
Abstract: Katzung KG, LeRoy JM, Boley SP, Thomas AJ, Stellpflug SJ, Holger JM, Engebretsen KM. Randomized Controlled Study Comparing High Dose Insulin (HDI) to Vasopressors or Combination Therapy in Refractory Toxin-Induced Cardiogenic Shock (TICS). J Med Toxicol (2016); 12:3-47. Abstract #1.
Publication: Katherine G. Katzung, Jenna M. Leroy, Sean P. Boley, Samuel J. Stellpflug, Joel S. Holger & Kristin M. Engebretsen (2019) A randomized controlled study comparing high-dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock, Clinical Toxicology, 57:11, 1073-1079, DOI: 10.1080/15563650.2019.1580372
Nathan Menke, MD
VA Pittsburgh Healthcare System
Utilizing Machine Based Learning Algorithms to Predict Mortality in Acetaminophen Overdose.
Award Amount: $10,000
Abstract: Menke N, Pizon A, Menke M. Utilizing a machine-based algorithm to predict mortality in acetaminophen overdose. J Med Toxicol 2017;13:3-46 (abstract #6)
Jeffrey, Lai, MD
University of Massachusetts Medical Center
"TeleSUDE - A Telemedicine-based Substance Use Disorder Evaluation to facilitate addiction treatment referrals after near-fatal opioid overdose"
Tim Wiegand, MD
University of Rochester Medical Center
"Does Direct Medical Toxicology: Bedside Care Improve Upon Poison Center Based Protocols for Pediatric Antidepressant Ingestions?"
Abstract: Wiegand TJ, Do MT, Jones C and Seplaki C. Medical Toxicology bedside consultation provides enhanced clearance compared to Poison Center based protocols in pediatric antidepressant ingestions. Presentation at the 2018 American College of Medical Toxicology (ACMT) Annual Scientific Meeting, Washington DC April, 2018. Also published in the Journal of Medical Toxicology March 2018; 14(1): 3-67 (abstract # 166).
Anthony Pizon, MD and colleagues
The University of Pittsburgh Medical Center
"Effects of Specialty Care on Cost and Length of Stay Following Hospitalization of the Poisoned Patient"
Abstracts:
- Menke NB, King AM, Lynch MJ, Abesamis MG, Saul MI, Pizon AF. Effects of medical toxicology speciality care on resource utilization during hospitalization of the poisoned patient. J Medical Toxicology 2015;11:6.
- Menke NB, King AM, Lynch MJ, Abesamis MG, Saul MI, Pizon AF. An inpatient toxicology service leads to increased hospital revenue by significantly increasing the number of transferred poisoned patients. J Medical Toxicology 2015; 11: 31
- Menke NB, King AM, Lynch MJ, Abesamis MG, Saul MI, Pizon AF. Effects of medical toxicology specialty care on length of stay following hospitalization of the poisoned patient. J Medical Toxicology 2015; 11: 31-32.
Publication: King, A. M., Danagoulian, S., Lynch, M., Menke, N., Mu, Y., Saul, M., Abesamis, M., Pizon, A. The Effect of a Medical Toxicology Inpatient Service in an Academic Tertiary Care Referral Center. J. Med. Toxicol. (2019) 15:12–21
Previously, this award was a jointly sponsored research grant offered by the Medical Toxicology Foundation and the Emergency Medicine Foundation (EMF). The goals of the grant were: 1) to promote toxicology-related research; 2) to advance emergency toxicology care; and 3) to facilitate the academic growth and development of future researchers in emergency medicine and toxicology by investing in the future of the specialty of emergency medicine and its sub boards. A total of six outstanding projects were awarded the MTF / EMF Research Grant between 2012 and 2019.
Daniel Nogee, MD
Yale New Haven Hospital
Award Amount: $10,000
Abstract: Winner of the 2019 ASM Shark Tank for his presentation, “Machine Learning Enhanced Diagnosis of Toxic Exposures”
Dalia Alwasiyah, MD
Carolinas Medical Center
“Urinary Gadolinium Levels: A Possible Indicator of Long-Term Retention after Contrast Enhanced MRIs”
Award Amount: $10,000
Mentor: Michael Beuhler, MD
Abstract: Alwasiyah, D., Murphy, C., Jannetto, P., Hogg, M., Beuhler, M. Urinary Gadolinium Levels After Contrast Enhanced MRI in Individuals with Normal Renal Function. J. Med. Toxicol. (2019) 15: 53.
Publication: Alwasiyah, D., Murphy, C., Jannetto, P. et al. Urinary Gadolinium Levels After Contrast-Enhanced MRI in Individuals with Normal Renal Function: a Pilot Study J. Med. Toxicol. (2019) 15: 121.
Christina Nussbaum, MD
Brody School of Medicine, East Carolina University
“Naltrexone as an antidote to prevent delayed neuropsychological disabilities from acute poisoning with the sarin analogue diisopropylfluorophosphate”
Award Amount: $10,000
Mentor: William Meggs, MD
Abstract: Nussbaum C, Meggs W, Brewer K, Fletcher P, Jr., Tran T, O’Rourke D, Dewitt J. Naltrexone as an Antidote to Prevent Delayed Neuropsychological Disabilities from Acute Poisoning With the Sarin Analogue Diisopropylfluorophosphate. Annals of Emergency Medicine 2017; 70:138 (Abstract 350).
Lindsay Fox, MD
Icahn School of Medicine at Mount Sinai
“Understanding Relationships Between Opioid Prescribing, Patient Characteristics, and Overdose”
Award Amount: $5,000
Mentor: Alex Manini, MD
Abstracts:
- Fox LM, Gestal C, Jalloh Y, Harper-Brooks A, Beicer A, Manini AF. Survey of prescription opioid knowledge and use patterns among ED patients that were prescribed opioid medications. Clin. Tox. 2016; 54:8.
- Fox LM, Hoffman RS, Vlahov D, Manini AF. Clinical risk factors in emergency department patients with prescription opioid overdose. Acad Emerg Med. 2015; 22: S1.
- Fox LM, Gestal C, Jalloh Y, Harper-Brooks A, Tapia B, Manini AF. Prescription opioid use and knowledge of overdose prevention strategies among ED patients. J. Med. Toxicol. 2015; 12:3-47 (abstract #86).
- Fox LM, Hoffman RS, Vlahov D, Manini AF. Clinical Risk Factors in ED Patients with Prescription Opioid Overdose. J. Med. Toxicol. 2015; 11: 2.
Publications:
- Fox LM, Hoffman RS, Vlahov D, Manini AF. Risk factors for severe respiratory depression from prescription opioid overdose. Addict Abingdon Engl 2017
- Fox LM, Hoffman RS, Vlahov D, Manini AF. Risk factors for severe respiratory depression from prescription opioid overdose. Addiction. 2018;113(1):59–66. doi:10.1111/add.13925
Jennifer Parker Cote, MD
Brody School of Medicine, East Carolina University
“Efficacy of Trypsin in Treating Coral Snake Envenomation in the Porcine Model”
Award Amount: $5,000
Mentor: William Meggs, MD
Abstract: Parker-Cote JL, O’Rourke D, Brewer KL, Lertpiriyapong K, Girard J, Bush SP, Miller SN, Punja M, Meggs WJ. Efficacy of trypsin in treating coral snake envenomation in the porcine model. J Med Toxicol 2015;11:2
Publication: Parker-Cote JL, O’Rourke D, Brewer KL, Lertpiriyapong K, Girard J, Bush SP, Miller SN, Punja M, Meggs WJ. Efficacy of trypsin in treating coral snake envenomation in the porcine model. J Med Toxicol 2015;11:430-432
James Cao, MD
Carolinas Medical Center
“Point of Care Testing in Setting of Nitromethane and Methanol Co-ingestion Will Not Mask True Creatinine, Anion Gap, or Osmolar Gap”
Award Amount: $5,000
Mentor: Michael Beuhler, MD
Abstracts:
- Cao D, Maynard SM, Mitchell-Smith AM, Kerns WP, Beuhler MC. Point-of-Care Testing in Setting of Nitromethane and Methanol Co-Ingestion Will Not Mask True Creatinine, Anion Gap, or Osmolar Gap. Journal of Medical Toxicology. 2014;10(1):65-66.
- Cao D, Maynard SM, Mitchell-Smith AM, Kerns WP, Beuhler MC. Point-of-Care Testing in Setting of Nitromethane and Methanol Co-Ingestion Will Not Mask True Creatinine, Anion Gap, or Osmolar Gap. Ann Emerg Med 2013;62:S42-S43.
Publication: Cao D, Maynard S, Mitchell AM, Kerns WP, Beuhler M. Point of care testing provides an accurate measurement of creatinine, anion gap, and osmolal gap in ex-vivo whole blood samples with nitromethane. Clin Toxicol 2014;52:611-617
Forrest Mahony, MD
"Detecting Harmful Algal Blooms (HABs) in New England Sea Turtles"
Fellow, University of Massachusetts Chan Medical School
Worcester, MA