Source: Verywell Health
Publication Date: Sept 4, 2026
Medical Toxicologist(s): Kelly Krisna Johnson-Arbor, MD
Keywords/Topics: vitamin B6, supplements, nerve damage

Verywell Health: High-Dose Vitamin B6 May Increase the Risk of Nerve Damage

“Vitamin B6 toxicity is rare unless someone consumes about 20 times the recommended daily amount consistently, said Kelly Krisna Johnson-Arbor, MD, a medical toxicologist at MedStar Georgetown University Hospital.

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Taking high doses of B6 may cause numbness, a pins-and-needles sensation, or pain in your legs, impairing your ability to walk.

“Basically, it’s toxic to nerve cells,” Johnson-Arbor said.

These symptoms are associated with more than 100 causes, not just vitamin B toxicity.6 If you do experience these symptoms, it is especially important to mention your B6 regimen to your healthcare provider because they might not initially think about B6 as the culprit, she added.

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If you take a multivitamin or a standalone B6 supplement, check the label to see how much vitamin B6 it contains so you can track your total daily intake.”